The findings also may help other researchers identify cancer stem cells by taking into account the cancer’s genetic signature. For patients, optimal treatment may rely on a combined mix of the tumor genotype and its own tumor-propagating cell phenotype. Our idea can be that, even though many patients’ tumors may look equivalent, to be able to offer truly individualized and effective targeted therapy, we need to know the genotype of a patient’s tumor and successfully identify the cells that maintain that tumor, stated Curtis.. Cancer stem cells might vary from tumor to tumor, say researchers Cancer stem cells have enticed scientists because of the potential to provide more durable and widespread cancer cures by identifying and targeting the tumor’s most voracious cells.‘Around 17 % of individuals with colorectal malignancy possess a tumor that carries a mutated PIK3CA gene,’ says Boris Pasche, M.D., Ph.D., director of the UAB Division of Oncology and Hematology. ‘Hence, more than one in every six patients with locally advanced colorectal tumor may reap the benefits of this therapy. ‘ Every year, a lot more than 140,000 Americans are diagnosed with colorectal cancer, and a lot more than 50,000 people die from the condition. Colorectal cancer is the third most common cause of death from cancers in the usa and the fourth world-wide. Over the past decade, little improvement has been manufactured in the treating locally advanced colorectal cancer, which is thought as cancer which has spread to nearby lymph or tissue nodes but has not metastasized, or spread to additional organs.